Dr. Lyon on Huberman Lab: Urolithin A and Muscle Health

Dr. Gabrielle Lyon, a renowned expert in muscle-centric medicine, is an accomplished board-certified physician and a distinguished New York Times Bestselling author, lauded for her latest work, FOREVER STRONG: A New, Science-Based Strategy for Aging Well. Dr. Lyon is at the forefront of modern medicine, focusing on optimizing muscle health to promote longevity and combat obesity, heart disease, and diabetes.

Dr. Lyon recently appeared on the highly popular Huberman Lab podcast, hosted by Stanford neuroscientist Dr. Andrew Huberman. Huberman is a tenured professor of neurobiology and ophthalmology at Stanford. He is widely recognized for his research on brain function, behavior, and health optimization. Dr. Huberman's podcast is highly respected in the scientific community, featuring in-depth discussions with leading experts on various topics related to health, wellness, and performance.

During their in-depth discussion on nutrition and supplementation, Dr. Lyon highlighted Urolithin A as a key supplement for promoting muscle health and longevity! This endorsement is particularly exciting for us at Timeline, as Mitopure which is a pure clinically validated Urolithin A supplement, is the cornerstone of our nutritional supplements and skincare products.

The importance of muscle health for longevity

Dr. Lyon: "Muscle is the organ of longevity and we've really got to start thinking about it differently. It's not just about aesthetics, it's not just about strength, it's about health span. It's about quality of life. It's about reducing all-cause mortality."

This statement represents a paradigm shift in how we view muscle tissue. Traditionally, muscles have been associated primarily with physical strength and appearance. However, Dr. Lyon's statement underscores a much broader and more crucial role for muscle in our overall health. Skeletal muscle is not just a collection of fibers that allow us to move; it's a metabolically active organ that plays a vital role in numerous bodily functions.

Resistance and endurance training to maintain muscle mass

Throughout the podcast, the discussion emphasized the importance of resistance training for maintaining muscle mass and overall health. It's clear that both Dr. Lyon and Dr. Huberman view resistance training as a crucial component of a healthy lifestyle, particularly as we age.

Some supplements can also assist with resistance and endurance results. Mitopure® had positive effects on muscle endurance in individuals, while Urolithin A had exercise-like effects. Timeline’s Mitopure® supplements are known to assist with training and help you improve muscle health.

The role of protein in muscle health

Dr. Lyon: "There's a meal threshold for skeletal muscle health and that meal threshold is a minimum of 30 grams [of leucine]. Now that would equal a four 4 and a half ounce steak, dare I say six eggs which is a lot of eggs at one time, or a scoop of whey protein."

While protein intake is crucial, Dr. Lyon's discussion highlights that it can be challenging to naturally integrate the required amount of protein into your diet. Protein supplements can help you get all the grams of protein you need, while other supplements can support muscle health in other ways.

The power of supplements for muscle health and longevity

Huberman: “Generally supplements often can have their place. We talked a little bit about creatine; I and many other people supplement with 5 to 10 grams of creatine monohydrate per day… what are your thoughts on creatine monohydrate, and what other supplements do you recommend…”

Dr. Lyon: “So creatine monohydrate is wonderful and particularly we're seeing a lot of benefits in women, postmenopausal women and older. The other supplement is Urolithin A.”

Urolithin A: A new frontier in longevity

The enthusiasm Dr. Lyon has for Urolithin A stems from its unique properties and benefits for human health. She explains:

Urolithin A is a postbiotic made from the gut microbiome, and there's a percentage of people that can make it and the majority of individuals cannot make it [naturally]... the connection which I find fascinating is a gut-muscle connection.Dr. Gabrielle Lyon

Urolithin A stands as a powerful postbiotic, carrying phenomenal benefits for the gut-muscle axis. However, the majority of individuals cannot make this powerful compound, and those unable to make Urolithin A, tend to have less diversity and richness in their microbiota.

Dr. Lyon: "It's made in the gut from the gut microbiome from things like pomegranate or walnut, it's made from something called an ellagitannin. And it is really what I think of as this gut-muscle connection which I do believe is going to be the next frontier."

At Timeline, we share this vision. Our research and product development have long focused on the intricate connections between gut health, mitochondrial function, and overall wellness. The recognition of Urolithin A's potential by respected experts like Dr. Lyon validates our approach and reinforces the importance of our work.

Supplementing Urolithin A to promote mitophagy

Dr. Lyon: “Individuals that take Urolithin A, I happen to be one of them, there are many papers out there that it improves mitophagy which is the health of mitochondria the turnover of mitochondria helps with the renewal of mitochondria, but what's so fascinating is there are trials in human individuals that it increases strength and endurance."

Over 15 years of research from top institutions around the globe showcase the safety and efficacy of Mitopure, and it’s been clinically proven to induce mitophagy in humans.^[1]

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Dosage recommendations

Dr. Lyon: "So I take between 500 and 1000mg of Urolithin A. Really, I wish that I had actually created this [compound] or found this out. Truly, if I could make one supplement, I know I would probably make a mix of Urolithin A with creatine and some whey protein and maybe uh 25 milligrams of collagen, and I would have my perfect supplement."

This recommended dosage aligns with the amounts found in Timeline's products, which are based on extensive scientific research and clinical trials.

The importance of purity

While Dr. Lyon's endorsement of Urolithin A is exciting, it's important to note that not all supplements are created equal. At Timeline, we pride ourselves on the purity and quality of our Urolithin A. Our proprietary Mitopure® is the world’s first clinically tested Urolithin A supplement. And our products are are NSF for Sport and Clean Label Certified.

Mitopure®: Beyond muscle health

While Dr. Lyon primarily discussed Urolithin A in the context of muscle health, it's important to note that its benefits extend far beyond. At Timeline, our research has shown that topical application of Mitopure® has benefits for skin health, which is why we developed our skincare line.

The ability of Mitopure® to support mitochondrial function doesn't just benefit muscle cells; it can also help rejuvenate skin cells and is clinically proven to reduce signs of aging, improving overall skin health. This multi-faceted approach to wellness is at the core of Timeline's philosophy – recognizing that true health comes from supporting the body's fundamental cellular processes.

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Conclusion

The recognition of Urolithin A by respected experts like Dr. Lyon on platforms like the Huberman Lab podcast is a testament to the growing importance of this compound in the field of health and longevity. At Timeline, we're proud to be pioneers in this field, providing high-quality, scientifically-backed Mitopure® products to support optimal health and wellness.

As we continue to learn more about the "gut-muscle connection" and the wide-ranging benefits of Mitopure®, we look forward to developing even more innovative ways to help people harness the power of this remarkable compound.

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