Mitopure and Niacinamide: A Power Due for Skin Longevity

True skin longevity isn’t just about hydration and antioxidants—it’s about giving your skin what it really needs.

Your skincare should deliver visible results while also addressing the fundamental drivers of aging. That’s why we’ve combined the classics with the cutting edge, pairing niacinamide—a trusted skincare staple—with Mitopure®, the first bioactive clinically proven to re-energize cells.

Niacinamide has long been celebrated for strengthening the skin barrier, evening tone and supporting cellular repair. Mitopure represents the forefront of longevity science, revitalizing skin cells by optimizing mitochondrial health.

By blending the trusted and transformative ingredients, Timeline’s formulations redefine what’s possible for skin longevity. Read on to discover the unmatched benefits of this duo.

Topical Niacinamide for Skin Longevity

Niacinamide, also known as vitamin B3, is a water-soluble vitamin celebrated for its broad range of skincare benefits. It is one of the most researched and versatile active ingredients in dermatology, making it a staple in many skincare formulations.

1. Niacinamide protects the skin. Niacindimine has antioxidant-like properties, helping to neutralize free radicals and reduce oxidative stress by supporting the skin’s natural defense mechanisms.^[1]
2. Niacinamide supports hydration. By boosting the production of ceramides, niacinamide strengthens the skin’s lipid barrier, reducing water loss. It also carries humectant properties, increasing the skin's capacity to attract water.
3. Niacinamide evens skin tone. Regular use can smooth uneven skin texture and brighten the complexion, addressing hyperpigmentation and acne scars.
4. Niacinamide preserves skin structure. Niacinamide stimulates the production of vital structural proteins like collagen, elastin, and keratin. It can also prevent sugar-induced glycation, a process that leads to sallow skin.

Not All Niacinamide Products Are Created Equal

Seeing niacinamide in your ingredient list does not guarantee results. Opt for clinically-trialled compositions to ensure efficacy.

The Timeline Skin Products incorporate niacinamide in sophisticated formulations that ensure long-term stability with no irritation or skin sensitization. All our products are clinically tested and produce high-quality results.^[2]

Topical Mitopure® for Skin Longevity

Timeline Skin Care pairs the benefits of niacinamide with Mitopure’s® clinically proven results to address skin aging at its source.

What Makes Mitopure® Unique?

Mitopure®, a bioactive form of Urolithin A, is recognized for its role in mitochondrial health.

The mitochondria are the powerhouses of our cells, generating the energy needed for vital functions, including skin repair and renewal. As we age, mitochondrial efficiency declines, leading to reduced cellular energy and impaired skin function.^[3]

Mitopure® addresses this decline by enhancing mitophagy (i.e. the selective recycling of damaged mitochondria) and improving mitochondrial health biomarkers.

Clinically Proven Benefits of Mitopure®

Mitopure® has been built on the back of 15 years of dedicated research. It has a unique mechanism of action that is not replicated by other active ingredients. Some of the impacts of topical Mitopure® include the following:

1. Mitopure® targets intrinsic skin aging. Mitopure® targets the biological process that contributes to skin aging. It’s clinically proven to significantly upregulate genes associated with collagen organization, making them behave like those in younger skin. This restores the skin’s structural integrity, reducing sagging and fine lines.
2. Mitopure® protects skin from photodamage. Sun damage is the number one contributor to extrinsic (i.e. environmental) aging. According to recent studies, Mitopure® offers robust protection against UV-B-induced damage.
3. Mitopure® diminishes wrinkles. In clinical trials, topical Mitopure® visibly reduced wrinkle depth and volume in just two weeks time.

The Synergism of Niacinamide and Mitopure®

Timeline Skincare is the only line of skin care products with the powerful combination of Mitopure and Niacinamide.

Recent 3-week user trials on products formulated with these two powerhouse ingredients—The Serum, The Night Cream, and The Day Cream—underscored the combined efficacy across hydration, protection, rejuvenation, and overall skin health. Here’s what the trials reveal:

The Serum: Instant Lift and Long-Term Renewal

Niacinamide’s barrier-repairing qualities combine with Mitopure’s cellular rejuvenation properties to reveal the following changes.

• Immediate Effects:
  • 77% experienced a deep, instant tightening and lifting effect for a visibly firmer complexion.
  • 100% observed their skin felt immediately hydrated, nourished, and supple.
• Longterm Benefits:
  • 80% agreed their skin looks more youthful and visibly renewed.
  • 90% felt their skin feels protected, stronger, and revitalized.

The Serum

Bestseller

4.6 · 126 reviews

Lifts the skin. Powered by Mitopure®

Buy now

The Night Cream: Overnight Transformation

Niacinamide works on the surface to strengthen the skin, Mitopure activates cellular repair processes, helping the skin look and feel renewed by morning.

• Morning Results:
  • 80% woke up re-energized with a more youthful appearance.
  • 83% agreed their skin awakens with a healthy glow, morning after morning.
• Longterm Benefits:
  • 93% believed their skin feels protected, stronger, and revitalized.
  • 87% thought their skin looks visibly firmer, more lifted, and elastic.

The Night Cream

4.7 · 124 reviews

Regenerates the skin's appearance. Powered by Mitopure®

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The Day Cream: Radiance and Resilience

Niacinamide’s brightening properties complement Mitopure’s potential to slow skin aging, creating a comprehensive day cream that supports and protects the skin.

• Immediate Effects:
  • 100% believed skin feels immediately hydrated, nourished, and supple.
  • 100% thought their skin looks more radiant, brighter, and glowing with health.
• Longterm Benefits:
  • 87% agreed their skin’s texture looks and feels redensified and with more volume.
  • 90% observed their skin feels protected, stronger, and revitalized.
  • 83% stated their skin looks more youthful and visibly renewed.

The Day Cream

4.6 · 89 reviews

Redensifies the skin's appearance. Powered by Mitopure®

Buy now

The Timeline Skin Products: A Proactive Approach to Skin Longevity

For optimal skin health, it's not just about one ingredient—it’s about how they work together.

That’s why the Timeline Skincare pairs niacinamide with Mitopure® to create a powerful synergy that supports cellular energy production on multiple fronts.

By incorporating both niacinamide and Urolithin A into your skincare routine, you are ensuring a multi-faceted approach to skin health. This powerful combination boosts cellular energy and optimizes skin longevity, targeting the root causes of aging and skin damage.15

With Timeline’s carefully crafted formulations, your skin will be nurtured from within, enhancing its ability to regenerate, repair, and radiate.

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