How to Select the Most Effective Urolithin A Supplement
Ever wonder why supplements promise the world but rarely deliver? Clinical research, third-party testing, and validated claims make the difference.
What to know
Mitopure is the #1 doctor-recommended Urolithin A supplement, trusted for its superior purity, clinically proven benefits, and rigorous scientific backing.
Mitopure is the only Urolithin A supplement to be favorably reviewed by the FDA (GRAS). It is also NSF for Sport and Clean Label Certified, ensuring the highest safety and quality of our products.
Over five gold-standard clinical studies have been conducted using Mitopure, validating its benefits.
Mitopure and all Timeline products are formulated by a team of leading doctors and scientists in Switzerland.
Our proprietary Urolithin A formulation is backed by over 15 years of dedicated research and multimillion-dollar investments.
If you’re diving into the world of Urolithin A supplements, you’re likely familiar with their ability to supercharge cellular energy and support healthy aging. Unfortunately, not all Urolithin A supplements are created equal. Some deliver proven benefits, while others rely more on clever marketing than solid science.
So, how do you separate the best from the rest? With so many options out there, here’s what you need to know.
1. Research-Backed: Science vs. Pseudoscience
Not all scientific theories translate into real-world results. Genetics, environment, and lifestyle all influence how the body responds to a compound, which is why clinical research is essential to establish the efficacy of dietary supplements.
Steering clear of borrowed research
Do you often wonder why supplements promise miracle benefits but seldom deliver?
The supplement industry is filled with bold claims. Many brands piggyback off of real scientific breakthroughs without testing their own compounds. They may use lower-quality ingredients while claiming the benefits of someone else's research. Often, supplement brands will use different formulations or a different dose than has been clinically studied but still use that research to support the benefits of their products.
This leads to a misalignment between what’s studied, what works, and what’s sold.
Mitopure: The First Clinically Tested Urolithin A
Mitopure® is the first Urolithin A supplement that has undergone gold-standard, double-blind, placebo-controlled human trials, with results published in top-tier scientific journals, including Nature, JAMA Network, and Cell Reports Medicine.
Mitopure Softgels
Bestseller4.4 · 3060 reviews
The simplest form of Mitopure
Our founders are a team of doctors and scientists who have been researching this molecule for over 15 years, studying its mechanism of action, safety, and efficacy. At Timeline, we have an entire team of leading experts in mitochondrial health and longevity who are dedicated to unlocking the full potential of Mitopure. Through more than a decade of research, we have optimized dosing strategies, mapped its precise impact on mitochondrial function, and ensured its superior bioavailability and long-term safety.
Dr. Mark Hyman shares: “I rarely get excited about one specific product because I know that getting healthy requires a systems-based approach, but after seeing the research on Mitopure (Urolithin A), I knew that I had to start taking it.”
When you choose Mitopure, you’re not just taking a supplement—you’re benefiting from decades of pioneering research, pharmaceutical-grade production, and an unwavering commitment to scientific integrity.
Mitopure’s benefits, like improved cellular energy and muscle strength, are based on real data, not assumptions. Other forms of Urolithin A lack these clinical studies, making their claims unsubstantiated.
Without published human trials, claims remain speculative at best and harmful at worst.
2. Quality: Pure vs. Untested
Many supplements may contain impurities (i.e., heavy metals, added ingredients, etc.) or low-quality extracts, making them less effective, ineffective, or potentially even dangerous.
Regulatory oversight: what you need to know
Unlike pharmaceuticals, dietary supplements are not approved by the FDA before they go to market. Under the DSHEA (Dietary Supplement Health and Education Act), the responsibility for safety, labeling, and efficacy falls on the manufacturer.
This means that choosing a trustworthy brand is essential. Without strict pre-market regulations, many supplements make unverified claims using preclinical data or cherry-picked studies instead of published human clinical trials.
The highest standard
Timeline’s Mitopure is produced to the highest standards, ensuring purity and potency.
We have an entire team dedicated to quality at every stage, from sourcing and testing ingredients to overseeing manufacturing, packaging, and shipping. This rigorous process ensures that every batch of Urolithin A meets the highest safety, efficacy, and consistency standards before it reaches our customers.
By maintaining strict quality control measures and adhering to industry-leading certifications, we guarantee that only the best Urolithin A is delivered.
The need for third-party testing
Without third-party testing, there is no way to verify that the stated dose on the label matches what’s inside the product you buy. Some supplements may contain less Urolithin A than advertised or even none at all. Additionally, undesirable ingredients may not be listed on the label, including heavy metals.
Our quality team ensures that our products are third-party tested and certified. Mitopure holds key certifications, including:
- FDA GRAS. This designation means that Mitopure has undergone a rigorous scientific review and is recognized by the FDA as safe for human consumption.
- Clean Label certification. This confirms that Mitopure is free from hidden dangers like heavy metals or pesticide residue.
- NSF certification. This sports nutrition certification indicates that Mitopure meets NSF strict standards for dietary supplements used by athletes; the product has been independently tested for purity, potency, and contaminants, including banned substances under major sports organizations.
These designations confirm that Mitopure meets the highest safety and quality standards. Our Softgels and Berry Powder do not contain animal products, making them suitable for plant-based and vegan lifestyles without compromising purity or effectiveness.
By contrast, many other Urolithin A supplements lack third-party testing. Without third-party testing, there is no way to guarantee safety, authenticity, and efficacy.
3. Dosage: Adequate vs. Improper
Research shows that 500-1000mg of Urolithin A daily[2] is best to achieve cellular and physical benefits. [1]
Many other brands sell doses that are far lower or higher than the amount needed to produce a real benefit.
Liposomal and other formulations
Some brands claim that liposomal (or other) Urolithin A formulations enhance absorption, but there is no published scientific evidence supporting this claim. To date, no published clinical studies show that other Urolithin A formulations improve bioavailability or efficacy.
4. Reliability: Backed By Top Thought Leaders
Choosing a supplement from a trusted, research-driven company is crucial for ensuring efficacy and safety. Timeline is supported by a distinguished scientific advisory board with leading researchers in the longevity field, including Dr. Eric Verdin, head of the Buck Institute for Research on Aging.
Mitopure has testimonials and endorsements from leading experts across multiple fields, including longevity science, mitochondrial research, functional medicine, sports nutrition, and fitness performance.
Among our key partners are Dr. Mark Hyman, a pioneer in functional medicine, and Dr. Gabrielle Lyon, a leading expert in muscle-centric medicine.
Mitopure is also known to enhance muscle health. We collaborate with elite fitness and sports performance experts. Their real-world experience, combined with our scientific research, ensures that Timeline products are designed to deliver measurable benefits for both everyday health and peak physical performance.
With science, expertise, and real-world results behind every dose, you can trust that Timeline delivers measurable benefits—so you can feel stronger, longer.
Make the choice backed by research. Choose Timeline.
The Bottom Line
Not all Urolithin A supplements deliver. Choosing a supplement backed by clinical research, third-party tested purity, and proper dosing is essential.
As the only clinically tested form of Urolithin A, Mitopure® is proven to enhance mitophagy and mitochondrial metabolism in skeletal muscle.[3]
When you select Mitopure®, you can trust that you're getting the benefits seen in the research, including:
Authors
Written by
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References
- ↑
Liu, S., D'Amico, D., Shankland, E., Bhayana, S., Garcia, J. M., Aebischer, P., Rinsch, C., Singh, A., & Marcinek, D. J. (2022). Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA network open, 5(1), e2144279. https://doi.org/10.1001/jamanetworkopen.2021.44279 (https://doi.org/10.1001/jamanetworkopen.2021.44279)
- ↑
Singh, A., D'Amico, D., Andreux, P. A., Fouassier, A. M., Blanco-Bose, W., Evans, M., Aebischer, P., Auwerx, J., & Rinsch, C. (2022). Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell reports. Medicine, 3(5), 100633. https://doi.org/10.1016/j.xcrm.2022.100633 (https://doi.org/10.1016/j.xcrm.2022.100633)
- ↑
Singh, A., D'Amico, D., Andreux, P. A., Fouassier, A. M., Blanco-Bose, W., Evans, M., Aebischer, P., Auwerx, J., & Rinsch, C. (2022). Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell reports. Medicine, 3(5), 100633. https://doi.org/10.1016/j.xcrm.2022.100633 (https://doi.org/10.1016/j.xcrm.2022.100633)
- ↑
Singh, A., D'Amico, D., Andreux, P. A., Dunngalvin, G., Kern, T., Blanco-Bose, W., Auwerx, J., Aebischer, P., & Rinsch, C. (2022). Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. European journal of clinical nutrition, 76(2), 297–308. https://doi.org/10.1038/s41430-021-00950-1 (https://doi.org/10.1038/s41430-021-00950-1)
- ↑
Liu, S., D'Amico, D., Shankland, E., Bhayana, S., Garcia, J. M., Aebischer, P., Rinsch, C., Singh, A., & Marcinek, D. J. (2022). Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA network open, 5(1), e2144279.
- ↑
Singh, A., D'Amico, D., Andreux, P. A., Fouassier, A. M., Blanco-Bose, W., Evans, M., Aebischer, P., Auwerx, J., & Rinsch, C. (2022). Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell reports. Medicine, 3(5), 100633. https://doi.org/10.1016/j.xcrm.2022.100633 (https://doi.org/10.1016/j.xcrm.2022.100633)
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