Pomegranate Extract vs. Juice

Wondering how to get all the nutritional benefits of pomegranates? Read on to learn more about how pomegranate extract compares to juice.

A pill capsule of pomegranate next to a cup of pomegranate juice
What to know
  • Pomegranate extract is rich in polyphenols like ellagitannins and ellagic acid, offering potent anti-inflammatory and antioxidant properties.

  • Pre-clinical studies found that pomegranates show promise for both men’s and women’s health, including prostate health for men and improved endometrial function for women.

  • Both pomegranate extract and juice offer significant health benefits, but the extract has a higher concentration of antioxidants.

  • Only pomegranate juice has been shown to reduce blood glucose spikes when consumed with high-glycemic foods, which is beneficial for managing diabetes risk.

  • Urolithin A, derived from pomegranate polyphenols, supports mitochondrial health and promotes healthy aging. Only 40% of the population can produce Urolithin A from pomegranates, which is overcome with Mitopure supplementation.

You may have heard about some of the health benefits of consuming pomegranate, a fruit that is rich in antioxidants. With all of the interest in pomegranate, there are now different ways to consume it, such as in the form of juice or as an extract in liquid and dry powder forms. Read on to find out more about the benefits of the different options.

Pomegranate extract powder texture

Pomegranate Extract Benefits

Pomegranate extract, derived both from the seed and peel, may be consumed as a dietary supplement and has been shown to have a number of potential health benefits. Pomegranate peel extract is rich in polyphenols, as the peel contains 10.4%–21.3% tannins[1], while the seeds are about 18% oil.[2]

Pomegranate extract has anti-inflammatory properties

Pomegranate extract has been shown to be anti-inflammatory, mainly due to the ellagitannins and ellagic acid it contains.[3] For example, a study in rats demonstrated that consuming pomegranate extract led to a decrease in inflammation after a surgical procedure.[4] As inflammation is associated with a number of chronic conditions, pomegranate extract holds promise when it comes to disease prevention.

Pomegranate extract is rich in polyphenols

Research also points to the numerous benefits of all of the different polyphenol compounds in pomegranate peel extract. These compounds include ellagic acid, which has several functions in the body, including:[5]

  • Antioxidant: Protects your cells from damage.
  • Anti-tumor Effects: May inhibit the growth of tumors.
  • Neuroprotection: Supports brain health.
  • Antiviral and Antibacterial Properties: Helps boost your immune system.

Pomegranate extract carries benefits for women

Studies suggest that pomegranate extract can be beneficial for women's health. For instance, research found that it improved endometrial function in rats with polycystic ovary syndrome, indicating potential benefits for women with this condition.[6]

Pomegranate extract carries benefits for men

Some studies have supported the extract’s use in the prevention or management of prostate cancer, erectile dysfunction, and benign prostatic hyperplasia. For example, one animal study showed that pomegranate extract helped testosterone-induced benign prostatic hyperplasia, which could be due to the antioxidant and anti-inflammatory properties of pomegranate.[7]

Pomegranate juice

The Benefits of Pomegranate Juice

Obviously, the benefits of pomegranate extract and juice overlap significantly. However, here are some of the distinct mechanisms of action.

Pomegranate juice carries antioxidant properties

Antioxidants play a role in the prevention of chronic disease. Pomegranate juice contains punicalagin, a substance that makes up part of the ellagitannins polyphenol family and accounts for more than half of the antioxidant activity of pomegranate juice[8].

Pomegranate juice carries antimicrobial properties

Pomegranate has demonstrated both antibacterial and antiviral activities, which is of interest, particularly given the possibility of widespread global virus pandemics.[9] Pomegranate juice holds promise in terms of the prevention and treatment of infection.

Pomegranate juice carries anti-inflammatory properties

Some studies have shown that pomegranate juice can be used as an anti-inflammatory agent[10]. Additional studies in humans with larger samples are needed to further understand the benefits.

Big pill capsule of pomegranate extract next. a tiny glass of pomegranate juice

Comparing Pomegranate Juice and Extract

Both pomegranate juice and extract carry health benefits, but studies comparing the two have revealed mixed results. Some research shows differences in their effects, while others do not.

One factor to consider is the variability in the activity of pomegranate juice and extract, depending on their source or method of preparation, which can make it difficult to draw clear conclusions.[11]

However, some key differences include:

Pomegranate peel extract has a stronger antioxidant profile

Pomegranate peel extract has a much higher antioxidant content than the juice and pulp extracts, thanks to its rich concentration of phenolics, flavonoids, and proanthocyanidins. This gives the peel extract more robust health-promoting properties, including more potent anti-inflammatory effects.[12]

Pomegranate juice is preferred for blood sugar control

Pomegranate juice has been shown to reduce the glycemic response when consumed with a high-glycemic food, such as bread. However, pomegranate extract (which includes the husk, internal membranes, and seed) did not have the same effect[13].

Pomegranate juice may offer more gut health benefits

Another study focused on gut bacteria showed similar beneficial effects of pomegranate juice and extract. Both enhanced the growth of beneficial gut bacteria. The authors suggest that pomegranate in these forms may work as a prebiotic, which has a beneficial effect on the gut.[14]

Urolithin A molecule

Urolithin A molecule

Pomegranate Supplement vs Urolithin A

Pomegranates are often celebrated as a rich source of Urolithin A precursors. Urolithin A is a postbiotic that results from the breakdown of polyphenols in pomegranates. It has gained significant attention due to its potential role in improving cellular energy and targeting muscle health. Urolithin A specifically supports mitochondrial health, the energy-producing powerhouses of our cells.


Can I get enough Urolithin A from pomegranates?

While pomegranate juice or extract is rich in Urolithin A precursors, only 40% of individuals have the gut microbiota required to produce Urolithin A. As a result, most people may not fully reap its benefits simply from consuming pomegranates.[15]

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Final words

Both pomegranate extract and juice have been shown to have potential health benefits that relate to functions such as anti-oxidation, anti-inflammatory, anti-microbial. Studies have been conducted that relate to particular aspects of health, and additional studies are needed to further understand these benefits. Urolithin A resulting from the breakdown of polyphenols in pomegranates is an important part of the rationale for consumption of juice and supplements and should be considered in the discussion of healthy aging.

Authors

Jinan Banna, PhD, RD

Written by

Professor of Nutrition & Scientific Writer

Jen Scheinman, MS, RDN, CDN

Reviewed by

Senior Manager of Nutrition Affairs

References

  1. Chen W, Liu R, Ha, ZB, & Li QZ. Chemical constituents and pharmacological action of pomegranate peel. Beijing Agriculture. 2015;17:97.

  2. Zarfeshany A, Asgary S, Javanmard SH. Potent health effects of pomegranate. Advanced biomedical research. 2014;3.

  3. Zarfeshany A, Asgary S, Javanmard SH. Potent health effects of pomegranate. Advanced biomedical research. 2014;3.

  4. Kahya V, Meric AY, Yazici M, Yuksel M, Midi A, Gedikli O. Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy. The Journal of Laryngology & Otology. 2011 Apr;125(4):370-5.

  5. Xiang Q, Li M, Wen J, Ren F, Yang Z, Jiang X, Chen Y. The bioactivity and applications of pomegranate peel extract: A review. Journal of Food Biochemistry. 2022 Feb 6:e14105.


  6. Ibrahim MA, Sadek MT, Eldin HS. Role of pomegranate extract in restoring endometrial androgen receptor expression, proliferation, and pinopodes in a rat model of polycystic ovary syndrome. Morphologie. 2021 May 19.

  7. Ammar AE, Esmat A, Hassona MD, Tadros MG, Abdel‐Naim AB, Guns ES. The effect of pomegranate fruit extract on testosterone‐induced BPH in rats. The Prostate. 2015 May;75(7):679-92.

  8. Howell AB, D'Souza DH. The pomegranate: effects on bacteria and viruses that influence human health. Evidence-Based Complementary and Alternative Medicine. 2013 Oct;2013.


  9. Howell AB, D'Souza DH. The pomegranate: effects on bacteria and viruses that influence human health. Evidence-Based Complementary and Alternative Medicine. 2013 Oct;2013.

  10. Danesi F, Ferguson LR. Could pomegranate juice help in the control of inflammatory diseases?. Nutrients. 2017 Aug 30;9(9):958.

  11. Kerimi A, Nyambe-Silavwe H, Gauer JS, Tomás-Barberán FA, Williamson G. Pomegranate juice, but not an extract, confers a lower glycemic response on a high–glycemic index food: Randomized, crossover, controlled trials in healthy subjects. The American journal of clinical nutrition. 2017 Dec 1;106(6):1384-93.

  12. Li, Yunfeng, et al. "Evaluation of antioxidant properties of pomegranate peel extract in comparison with pomegranate pulp extract." Food Chemistry 96 (2006): 254-260.

  13. Kerimi, A., Nyambe-Silavwe, H., Gauer, J., Tomás-Barberán, F., & Williamson, G. (2017). Pomegranate juice, but not an extract, confers a lower glycemic response on a high-glycemic index food: randomized, crossover, controlled trials in healthy subjects.. The American journal of clinical nutrition, 106 6, 1384-1393 . https://doi.org/10.3945/ajcn.117.161968.

  14. Li Z, Summanen PH, Komoriya T, Henning SM, Lee RP, Carlson E, Heber D, Finegold SM. Pomegranate ellagitannins stimulate growth of gut bacteria in vitro: Implications for prebiotic and metabolic effects. Anaerobe. 2015 Aug 1;34:164-8.

  15. Singh, A., D’Amico, D., Andreux, P.A. et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr 76, 297–308 (2022). https://doi.org/10.1038/s41430-021-00950-1

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. References: *Nutrition studies: 500mg Mitopure® have been shown to (1) induce gene expression related to mitochondria function and metabolism and (2) increase the strength of the hamstring leg muscle in measures of knee extension and flexion in overweight 40-65 year olds. Data from two randomized double-blind placebo-controlled human clinical trials. **Nutrition NOURISH Study: 500mg Mitopure® have been shown to deliver at least 6 times higher Urolithin A plasma levels over 24 hours (area under the curve) than 8 ounces (240ml) of pomegranate juice in a randomized human clinical trial.

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