Why You Need a Longevity Plan—And How to Create One

Learn how to create a personalized longevity plan with nutrition, movement, sleep, and cutting-edge strategies to optimize healthspan and vitality.

Longevity plan
What to know
  • A longevity plan focuses on increasing healthspan, not just lifespan, ensuring you live with vitality, strength, and purpose as you age.

  • Nutrition plays a critical role in aging well, with a whole foods diet. Fasting and caloric restriction may offer some added benefits.

  • Daily movement and structured exercise, including strength training and cardiovascular endurance, help maintain muscle mass and metabolic function.

  • Prioritizing sleep and recovery, as well as strategies for mindfulness and cognitive health should be part of any longevity plan.

  • Next-level strategies like Mitopure® can boost your foundational efforts, by targeting the biological process that contribute to aging.

You plan for your retirement and financial goals, as well as weddings, vacations, and other important life events. But have you ever considered building a longevity plan?

A longevity plan isn’t about simply extending your lifespan—although that may be a part of the equation. Instead, think of it as a plan to ensure your life is filled with vitality, strength, and purpose for as long as possible.

The reality is, longevity isn’t just a matter of chance—it’s something we can actively shape. By building a longevity plan, you’re investing in your future self, ensuring that as you age, you continue to feel strong, stay sharp, and live life to the fullest. Let’s explore what it takes to create a personalized strategy for thriving at every stage of life.

What is a Longevity Plan

When people hear the word longevity plan, they often think about extending their lifespan and pushing the limits of how long humans can live. However, a longevity plan goes far beyond that.

A longevity plan is a structured and proactive approach to aging well. It focuses on increasing your healthspan, or the number of years rich with vitality and meaning. By laying down the right foundation today—through smart nutrition, movement, recovery, and mindset shifts—you’re setting yourself up for a future where you’re not just living longer, but living better.

So, what exactly should be in your plan?

Core Pillars of a Longevity Plan

Long-lived individuals offer valuable inspiration for crafting your longevity plan. Take the Blue Zones, for example—regions around the world where people frequently live past 100. Research into these communities has identified key lifestyle traits contributing to a long and vibrant life.

While everyone's longevity plan will be different, there are a few fundamental elements that should serve as its foundation.

Blood Flow. Longevity Biometrics.

Longevity Biometrics

In order to know where you are going, you need to know where you are today. Regularly checking your biometrics will give you a foundation on which to build and will help to determine if the actions you are taking are keeping you on the right path.

Work with your healthcare provider to determine the best tests for you and how often you should be screened. Together, you will assess what values are out of range and what you can do to bring them back to an optimized level. Everyone's testing plan will look different and should be determined by your health care provider, however, here are a few to consider.

Please note that insurance may or may not cover these tests - talk to your doctor and insurance company before scheduling your test to avoid any surprise out-of-pocket expenses.

Blood work: In addition to the labs drawn at an annual check-up, consider testing insulin level, the inflammatory marker C-reactive protien, hormone levels, and thyroid function.

Physical longevity tests: Tests like V02 max, grip strength, and other physical tests can provide valuable insight into muscle strength, flexibility, and balance.

Body composition: Tests like the DEXA (Dual-Energy X-ray Absorptiometry) scan show you how much muscle and body fat you have, as well as provide crucial information on your bone density.

Nutrition

Nutrition

It has been well established that how you eat plays a role in how well you age. While there is much debate on the ideal longevity diet, we know that diets powered by whole foods, like the Mediterranean Diet, are consistently linked to lower levels of chronic disease and a longer life. Why? Because they are rich in essential nutrients like vitamins, minerals, fiber, antioxidants, and polyphenols.

Fiber

Fiber is the unsung hero of longevity due to the fact that it plays a key role in gut health, metabolic regulation, and cardiovascular function. A fiber-rich diet supports a diverse and thriving gut microbiome, which is increasingly recognized as a key player in longevity.

As we get older, our gut microbiome changes, making it critically important to fuel the microbes that reside in our gut. [1]The Dietary Guidelines for Americans recommends 25- 30 grams of fiber a day,[2] but studies suggest more may be better.[3]

To get 25-30 grams of protein a day, eat plenty of fiber-rich foods, including:

  • Beans and legumes
  • Whole grains
  • Fruits and vegetables
  • Seeds and nuts

Antioxidants and polyphenols

Antioxidants and polyphenols are potent plant compounds that support cellular function, combat oxidative stress, and promote longevity. Notably, every traditional diet followed by those in the Blue Zones includes a variety of plant-based foods rich in these bioactive compounds.[4]

Emerging research highlights an additional role of polyphenols in longevity—acting as prebiotics that nourish the gut microbiome. One noteworthy example is Urolithin A, a polyphenol-derived compound found in foods including pomegranates, walnuts, and berries.[5] Urolithin A supports mitochondrial function, the energy center of cells, which is critical for sustaining muscle health and overall vitality. Since mitochondrial decline is a hallmark of aging, optimizing their performance may be a key factor in healthy aging and longevity.[6]

Mitopure® is a clinically validated Urolithin A supplement that provides six times more Urolithin A than diet alone.[7] Clinical trials have demonstrated Mitopure's ability to trigger a crucial mitochondrial recycling process and support muscle health.[8]

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Fasting and Caloric Restriction

It’s not just what you eat. How much and when can also affect how well you age. Caloric restriction and fasting have been shown to activate longevity pathways by reducing inflammation, improving metabolic function, and promoting autophagya cellular recycling process that helps clear out damaged components.[9] The goal isn’t severe calorie deprivation but rather optimizing how and when you eat to encourage cellular repair and longevity while ensuring adequate intake of essential nutrients.

Exercise for longevity

Physical Activity

Movement is a cornerstone of a longevity plan. The way you move your body each day has a profound impact on your physical and mental health, ensuring that you remain strong, flexible, and resilient as you age. A well-rounded exercise strategy should include daily movement, endurance training, strength building, and flexibility work.

Daily Movement

One of the most significant factors influencing longevity is how much you move throughout the day. Long-lived individuals in Blue Zones don’t go to gyms and engage in the latest fitness trends. Instead, they naturally integrate movement into their daily lives through activities like walking, gardening, and household chores.[10]

Your longevity plan should include a meaningful strategy to reduce your time sitting and find ways to move more throughout the day. Simple shifts—like using a standing desk, incorporating walking meetings, or taking regular movement breaks—can be just as beneficial, if not more so, than a single intense gym session. Research has shown that prolonged sitting is linked to negative health outcomes, even in those who exercise regularly. Prioritizing consistent, low-intensity movement throughout the day is a powerful strategy for supporting longevity and overall well-being.[11]

Endurance Training

Dedicated time to build endurance or cardiovascular training is another key component of a longevity plan. Also called aerobic exercise, this type of training supports heart health, lung capacity, and overall stamina. By engaging in regular endurance training, you can increase your VO2 max, an indicator of cardiovascular fitness and an emerging biomarker for longevity.

Engaging in activities that elevate your heart rate helps maintain cardiovascular efficiency and cellular function, which are key for longevity.

  • Target 150 minutes weekly: The Physical Activity Guidelines for Americans recommend at least 150 minutes of moderate-intensity aerobic activity or 75 minutes of vigorous exercise per week.[12]
  • Best activities: Walking, jogging, swimming, cycling, and dancing are all excellent endurance exercises that support heart health and longevity. Choose one you enjoy doing so you are more likely to stick with it.
  • Zone 2 training: Moderate-intensity exercise, where you can still hold a conversation but feel slightly challenged, optimizes mitochondrial health and metabolic function.[13]

Strength Training

Maintaining muscle mass is one of the most important aspects of aging well. Sarcopenia, or the age-related loss of muscle, is associated with frailty, metabolic decline, increased risk of falls, and even death.[14] Strength training helps counteract these effects and promotes longevity.

  • Train at least twice a week: Aim for two to three sessions of resistance training per week, targeting all major muscle groups.
  • Best exercises: Squats, lunges, deadlifts, push-ups, and resistance band exercises all support functional strength and mobility.

Flexibility and Mobility

Flexibility and mobility are often overlooked but are crucial for longevity. Maintaining a good range of motion in joints and muscles helps prevent injuries, improves posture, and supports an active lifestyle.

  • Incorporate daily stretching: Dynamic stretching before exercise and static stretching after workouts improve flexibility.
  • Try yoga or pilates: These practices enhance mobility, balance, and core strength while reducing stress.
  • Focus on joint health: Movements like hip openers, spinal twists, and ankle mobility exercises help maintain functional movement patterns.
Recovery & Sleep

Recovery & Sleep

While nutrition and movement often take center stage in discussions about longevity, quality sleep and intentional recovery are just as critical for healthy aging. Sleep is when the body undergoes vital repair processes, while strategic recovery methods help reduce inflammation, enhance resilience, and optimize cellular function. Prioritizing deep, restorative sleep and incorporating science-backed recovery techniques can make a profound difference in how you age.

The Role of Sleep in Longevity

Sleep is essential for brain health, hormone regulation, and immune function—all of which impact longevity. A well-regulated circadian rhythm—the body’s internal clock that governs sleep-wake cycles—plays a crucial role in these processes. Poor sleep and circadian rhythm disruptions have been linked to an increased risk of chronic diseases, cognitive decline, and metabolic dysfunction.[15]

To optimize sleep for longevity:

  • Aim for 7-9 hours of quality sleep per night. Deep sleep is when cellular repair, memory consolidation, and hormonal balance occur.
  • Maintain a consistent sleep schedule. Going to bed and waking up at the same time daily helps regulate your circadian rhythm.
  • Optimize your sleep environment. Keep your bedroom cool, dark, and quiet to promote uninterrupted rest.
  • Limit blue light exposure before bed. Blue light from screens suppresses melatonin production, making it harder to fall asleep.

Recovery Strategies for Longevity

Beyond sleep, targeted recovery techniques can support cellular resilience, reduce inflammation, and enhance physical and mental well-being. This includes strategies like red light therapy, sauna, and cold plunge.

Mindset and mental health

Mindset and Mental Health

Longevity isn’t just about physical health. Mindset, stress levels, and sense of purpose play a profound role in how well you age. Studies show that individuals with a positive attitude toward aging tend to live longer, experience fewer chronic diseases, and maintain higher cognitive function. [16]Developing a strong mental framework for aging well involves stress management, lifelong learning, social connections, and cultivating a sense of purpose.

The Impact of Stress on Longevity

Chronic stress accelerates aging by increasing inflammation, impairing immune function, and disrupting hormonal balance. Elevated cortisol levels (the body’s stress hormone) are associated with cognitive decline, poor sleep, and increased risk of metabolic disease. Managing stress effectively is a crucial part of a longevity plan.

Here are some key strategies to enhance mental resilience:

  • Practice mindfulness & meditation – Mindfulness-based practices help regulate stress, improve focus, and enhance emotional well-being. Regular meditation has even been linked to increased gray matter in the brain.
  • Engage in lifelong learning – Keep your brain stimulated through reading, learning new skills or a language, or taking a course. Make this the year you try something new.
  • Foster social connectionsStrong relationships and social engagement are linked to lower levels of inflammation, reduced stress, and increased longevity.[17] Prioritize meaningful connections with family, friends, and your community. Don't wait for the invite, take the initiative to organize a get together with your community.
  • Cultivate a sense of purposeWhether through work, volunteering, hobbies, or finding a spiritual connection to the universe, feeling connected to the world we live in provides a sense of fulfillment, reduces stress, and fosters resilience, all of which contribute to a longer, healthier life.[18]
  • Have fun! Life can be stressful, so finding ways to laugh, be silly, and enjoy the day-to-day can play a meaningful role in your long-term health.
Next Level Strategies

Next-Level Longevity Strategies

For those looking to take their longevity plan beyond the fundamentals, advancements in supplements, technology, and personalized medicine are opening new doors to optimizing health and extending health span. By leveraging cutting-edge science and individualized interventions, you can further enhance cellular function, track key biomarkers, and tailor your approach to aging well.

Targeted Supplements for Longevity

While a nutrient-dense diet provides the foundation for good health, strategic supplementation can offer additional support in areas that food alone may not fully address.

Mitopure® provides a clinically validated dose of Urolithin A that most can’t meet through diet alone.[19] Research has shown that Mitopure can:

Improve mitochondrial health: After just four weeks of taking Mitopure®, significant improvements were observed in key markers of mitochondrial function and cellular energy production, supporting overall vitality and endurance.[20]

Improve muscle endurance – Our ENERGIZE trial demonstrated that 1000mg of Mitopure over 2 months improved muscle endurance in older adults by 17%.[21]

Improve muscle strength: Our ATLAS trial showed that 500 mg of Mitopure improved muscle strength by 12% after four months [22]

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Longevity Tech & Wearables

Advances in health technology allow for real-time tracking of key longevity markers, providing valuable insights into metabolic health, sleep quality, recovery, and cardiovascular function. Some next-level tools include:

  • Continuous Glucose Monitors (CGMs): Help optimize metabolic health by identifying how your body responds to different foods, stress, and exercise.
  • Wearable fitness & recovery devices: Tools like Oura Ring, Whoop, and Apple Watch track heart rate variability (HRV), VO₂ max, sleep quality, and movement patterns, helping you make data-driven lifestyle adjustments.

Personalized Medicine & Longevity Testing

Gone are the days of a one-size-fits-all approach to health. Personalized medicine uses advanced testing to create customized longevity plans based on your unique genetic, metabolic, and physiological profile. This includes tests like DEXA scans, biological age testing, and comprehensive blood panels.

  • DEXA Scans: Dual-Energy X-ray Absorptiometry, or DEXA, scans assess bone density and body composition.
  • Biological age testing: Methods like telomere length and epigenetic testing analyze how your lifestyle is impacting your health and longevity.
  • Comprehensive blood panels: Going beyond the standard bloodwork, these in-depth panels can offer detailed insights into inflammation biomarkers, hormone levels, insulin sensitivity and organ health.

Invest in Your Future Health Today

A longevity plan isn’t about chasing a longer life—it’s about ensuring that the years ahead are filled with vitality, strength, and purpose. Having a plan can help shape your energy, resilience, and independence in the decades to come. Whether it's fueling your body with the right nutrients, prioritizing daily movement, improving sleep quality, or leveraging cutting-edge science like Mitopure® and personalized health tracking, your efforts will pay off in the form of a healthier, more vibrant future. The best time to start? Right now. Your future self will thank you.

Authors

Jen Scheinman, MS, RDN, CDN

Written by

Senior Manager of Nutrition Affairs

Julie Faitg, PhD

Reviewed by

Lead Regulatory Affairs & Scientific Manager Alliances at Timeline

References

  1. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. Published online January 3, 2023. doi:10.1016/j.cell.2022.11.001

  2. Dietary Guidelines for Americans. Accessed January 20, 2025. https://www.dietaryguidelines.gov/

  3. Rough Up Your Diet. NIH News in Health. Accessed January 20, 2025. https://newsinhealth.nih.gov/2019/07/rough-up-your-diet

  4. Santacroce L, Bottalico L, Charitos IA, Haxhirexha K, Topi S, Jirillo E. Healthy Diets and Lifestyles in the World: Mediterranean and Blue Zone People Live Longer. Special Focus on Gut Microbiota and Some Food Components. Endocr Metab Immune Disord Drug Targets. 2024;24(15):1774-1784. doi:10.2174/0118715303271634240319054728

  5. D’Amico D, Andreux PA, Valdés P, Singh A, Rinsch C, Auwerx J. Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. Trends Mol Med. 2021;27(7):687-699. doi:10.1016/j.molmed.2021.04.009

  6. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. Published online January 3, 2023. doi:10.1016/j.cell.2022.11.001

  7. Singh A, D’Amico D, Andreux PA, et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr. 2022;76(2):297-308. doi:10.1038/s41430-021-00950-1

  8. Andreux PA, Blanco-Bose W, Ryu D, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019;1(6):595-603. doi:10.1038/s42255-019-0073-4

  9. Strilbytska O, Klishch S, Storey KB, Koliada A, Lushchak O. Intermittent fasting and longevity: From animal models to implication for humans. Ageing Res Rev. 2024;96:102274. doi:10.1016/j.arr.2024.102274

  10. Ungvari Z, Fazekas-Pongor V, Csiszar A, Kunutsor SK. The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms. GeroScience. 2023;45(6):3211-3239. doi:10.1007/s11357-023-00873-8

  11. Dunstan DW, Howard B, Healy GN, Owen N. Too much sitting--a health hazard. Diabetes Res Clin Pract. 2012;97(3):368-376. doi:10.1016/j.diabres.2012.05

  12. Physical Activity Guidelines for Americans | health.gov. Accessed May 8, 2023. https://health.gov/our-work/nutrition-physical-activity/physical-activity-guidelines

  13. Memme JM, Erlich AT, Phukan G, Hood DA. Exercise and mitochondrial health. J Physiol. 2021;599(3):803-817. doi:10.1113/JP278853

  14. Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet Lond Engl. 2019;393(10191):2636-2646. doi:10.1016/S0140-6736(19)31138-9

  15. Zimmet P, Alberti KGMM, Stern N, et al. The Circadian Syndrome: is the Metabolic Syndrome and much more! J Intern Med. 2019;286(2):181-191. doi:10.1111/joim.12924

  16. Tully-Wilson C, Bojack R, Millear PM, Stallman HM, Allen A, Mason J. Self-perceptions of aging: A systematic review of longitudinal studies. Psychol Aging. 2021;36(7):773-789. doi:10.1037/pag0000638

  17. Kim, E., Chen, Y., Nakamura, J., Ryff, C., & VanderWeele, T. (2021). Sense of Purpose in Life and Subsequent Physical, Behavioral, and Psychosocial Health: An Outcome-Wide Approach. American Journal of Health Promotion, 36, 137 - 147. https://doi.org/10.1177/08901171211038545.

  18. Kim, E., Chen, Y., Nakamura, J., Ryff, C., & VanderWeele, T. (2021). Sense of Purpose in Life and Subsequent Physical, Behavioral, and Psychosocial Health: An Outcome-Wide Approach. American Journal of Health Promotion, 36, 137 - 147. https://doi.org/10.1177/08901171211038545.

  19. Singh A, D’Amico D, Andreux PA, et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr. 2022;76(2):297-308. doi:10.1038/s41430-021-00950-1

  20. Andreux PA, Blanco-Bose W, Ryu D, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019;1(6):595-603. doi:10.1038/s42255-019-0073-4

  21. Liu S, D’Amico D, Shankland E, et al. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA Netw Open. 2022;5(1):e2144279. doi:10.1001/jamanetworkopen.2021.44279

  22. Singh A, D’Amico D, Andreux PA, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022;3(5). doi:10.1016/j.xcrm.2022.100633

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. References: *Nutrition studies: 500mg Mitopure® have been shown to (1) induce gene expression related to mitochondria function and metabolism and (2) increase the strength of the hamstring leg muscle in measures of knee extension and flexion in overweight 40-65 year olds. Data from two randomized double-blind placebo-controlled human clinical trials. **Nutrition NOURISH Study: 500mg Mitopure® have been shown to deliver at least 6 times higher Urolithin A plasma levels over 24 hours (area under the curve) than 8 ounces (240ml) of pomegranate juice in a randomized human clinical trial.

© 2025
© 2025